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KMID : 0376419950190020147
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Chonbuk University Medical Journal
1995 Volume.19 No. 2 p.147 ~ p.154
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A Study on the Histochemical and Enzyme Histochemical Characteristics of the Foreign Body-Induced Proliferated Synovial Membranes of the Rat Knee Joints
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이혜수
김영숙/강명재/최삼임/최호열/김상호
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Abstract
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Hypertrophy of the synovial membrane is an important feature of inflammatory lesions of the synovial membrane, but there is no information on the proliferation of the cells in the synovial membrane. Electron microscopically, synovial lining cells
are
consisted with phagocytic(type A) cell and fibroblast like(type B) cells. In this paper, to investigate the histochemical and enzyme histochemical characteristics of the foreign body induced proliferated synovial lining cells, at 1 and 3 day
after
injection of the foreign bodies(carbon particle) into the knee joint cavities of the rat, the histologic (H&E), histochemical (PAS) and enzyme histochemical (acid phosphatase, 5´-nucleotidase, and nonspecific esterase) stains were performed on
the
surgically removed synovial membranes.
Prominent hypertrophy of the synovial membranes with porliferation of the synovial lining cells, increased phagocytic macrophages, many inflammatory cell infiltration, dilated and congestive biood vessels, and collagen fiber proliferation of the
deeper
layer were recognized. Most of the phagocytes were shown in superficial and deep layer of the synovial membrane at 1 and 3 day after injection of foreign bodies, respectively. The proliferated synovial lining cells were stained with PAS, and
there
is no
mitotic figure in proliferated synovial lining cells.
In enzyme histochemical studies, the nonspecific esterase and 5´-nucleotidase activities were not prominent in proliferated synovial lining cells but the acid phosphatase activity was very strong compared with normal synoviai lining cells.
According to the above results, foreign body induced proliferated synovial lining cells may be type A cells, which were known phagocytes, and further studies for these cells will be performed.
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KEYWORD
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